Jules C Hancox Selected Research

Potassium Channels (Potassium Channel)

8/2023	Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue.
1/2021	In silico Exploration of Interactions Between Potential COVID-19 Antiviral Treatments and the Pore of the hERG Potassium Channel-A Drug Antitarget.
1/2018	Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker.
1/2018	Action potential clamp characterization of the S631A hERG mutation associated with short QT syndrome.
8/2015	hERG potassium channel inhibition by ivabradine may contribute to QT prolongation and risk of torsades de pointes.
4/2015	hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine.
3/2010	Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide.
8/2008	The hERG potassium channel and hERG screening for drug-induced torsades de pointes.
5/2004	Potent inhibition of human cardiac potassium (HERG) channels by the anti-estrogen agent clomiphene-without QT interval prolongation.
7/2003	Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652.

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Jules C Hancox Research Topics

Disease

25	Cardiac Arrhythmias (Arrythmia) 02/2024 - 01/2003
22	Torsades de Pointes (Torsade de Pointes) 01/2021 - 01/2003
12	Long QT Syndrome 08/2023 - 07/2003
11	Atrial Fibrillation 02/2024 - 04/2004
11	Short Qt Syndrome 11/2023 - 09/2006
9	Heart Failure 01/2022 - 07/2003
6	Sudden Death 11/2018 - 02/2003
4	Hypertrophy 01/2015 - 07/2003
3	Cardiotoxicity 11/2023 - 05/2004
3	Atrial Remodeling 01/2022 - 10/2011
3	Ventricular Tachycardia 08/2020 - 05/2005
3	Fibrosis (Cirrhosis) 01/2020 - 10/2011
3	Bradycardia 01/2020 - 08/2013
3	Acidosis 12/2019 - 01/2009
3	Ventricular Fibrillation 05/2016 - 07/2003
3	Nausea 01/2014 - 05/2013
2	Rett Syndrome (Rett's Disorder) 05/2022 - 10/2019
2	Seizures (Absence Seizure) 01/2020 - 05/2010
2	Heart Arrest (Cardiac Arrest) 01/2018 - 05/2016
2	Cardiac Sudden Death (Sudden Cardiac Arrest) 06/2014 - 01/2013
2	Hypokalemia 06/2014 - 08/2013
2	Heart Diseases (Heart Disease) 04/2014 - 08/2013
2	Vomiting 01/2014 - 05/2013
1	Cardiomyopathies (Cardiomyopathy) 11/2023
1	Respiratory Tract Infections (Respiratory Tract Infection) 09/2021
1	Ventricular Premature Complexes (Premature Ventricular Contraction) 01/2021
1	COVID-19 01/2021
1	Alzheimer Disease (Alzheimer's Disease) 01/2020
1	Critical Illness (Critically Ill) 01/2020
1	Epilepsy (Aura) 01/2020
1	Ischemia 09/2017
1	Sick Sinus Syndrome 09/2017
1	Eye Diseases (Eye Disease) 01/2017

Drug/Important Bio-Agent (IBA)

10	Potassium Channels (Potassium Channel)IBA 08/2023 - 07/2003
9	PotassiumIBA 08/2023 - 10/2008
8	Ether (Diethyl Ether)IBA 08/2023 - 07/2003
8	Anti-Arrhythmia AgentsIBA 08/2020 - 06/2003
6	Ion Channels (Ion Channel)IBA 01/2022 - 04/2004
4	Anti-Bacterial Agents (Antibiotics)IBA 09/2021 - 04/2006
4	IvabradineIBA 01/2017 - 04/2015
4	Clarithromycin (Biaxin)FDA LinkGeneric 04/2014 - 08/2013
3	Azithromycin (Zithromax)FDA LinkGeneric 09/2021 - 10/2013
3	MacrolidesIBA 09/2021 - 11/2013
3	Quinidine (Chinidin)FDA LinkGeneric 01/2018 - 09/2006
3	Disopyramide (Norpace)FDA LinkGeneric 01/2017 - 09/2006
3	Ranolazine FDA Link 10/2016 - 12/2010
2	CalciumIBA 02/2024 - 01/2015
2	CannabinoidsIBA 12/2023 - 01/2020
2	phenanthreneIBA 11/2023 - 01/2021
2	Sodium Channels (Sodium Channel)IBA 05/2022 - 06/2003
2	Erythromycin (Erycette)FDA LinkGeneric 01/2020 - 04/2014
2	ElectrolytesIBA 01/2020 - 01/2020
2	Biomarkers (Surrogate Marker)IBA 11/2018 - 08/2008
2	Adenosine Triphosphate (ATP)IBA 09/2017 - 12/2012
2	salicylhydroxamic acid (SHAM)IBA 03/2017 - 10/2011
2	Cytochrome P-450 CYP3AIBA 06/2014 - 04/2014
2	Citalopram FDA LinkGeneric 01/2014 - 10/2013
2	Protein Isoforms (Isoforms)IBA 09/2013 - 06/2007
2	Methadone (Dolophine)FDA LinkGeneric 09/2013 - 08/2013
2	Dronedarone FDA Link 04/2012 - 04/2004
2	Antipsychotic Agents (Antipsychotics)IBA 12/2006 - 02/2003
1	Organic Cation Transporter 2IBA 11/2023
1	Solute Carrier Family 22 Member 5IBA 11/2023
1	Carnitine (L-Carnitine)FDA LinkGeneric 11/2023
1	Systemic carnitine deficiencyIBA 11/2023
1	Petroleum (Crude Oil)IBA 11/2023
1	Polycyclic Aromatic Hydrocarbons (Polynuclear Aromatic Hydrocarbons)IBA 11/2023
1	Proteins (Proteins, Gene)FDA Link 01/2022
1	Antiviral Agents (Antivirals)IBA 01/2021
1	lopinavir-ritonavir drug combination (Kaletra)FDA Link 01/2021
1	HydrocarbonsIBA 01/2021
1	favipiravirIBA 01/2021
1	Atazanavir Sulfate (Reyataz)FDA Link 01/2021
1	remdesivirIBA 01/2021
1	GadoliniumIBA 01/2020
1	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2020
1	Donepezil (Aricept)FDA LinkGeneric 01/2020
1	Anticonvulsants (Antiepileptic Drugs)IBA 01/2020
1	Galantamine (Galanthamine)FDA LinkGeneric 01/2020
1	Rivastigmine (Exelon)FDA LinkGeneric 01/2020
1	Pentylenetetrazole (Metrazol)IBA 01/2020
1	Protons (Proton)IBA 12/2019
1	sarizotanIBA 10/2019
1	Hormones (Hormone)IBA 01/2019
1	ProlactinIBA 01/2019
1	Oxytocin (Pitocin)FDA LinkGeneric 01/2019
1	NS 3623IBA 01/2018
1	Acetylcholine (Acetylcholine Chloride)FDA Link 09/2017
1	Solifenacin Succinate FDA Link 07/2017
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 03/2017
1	Oxaliplatin (Eloxatin)FDA LinkGeneric 12/2016
1	triadinIBA 05/2016
1	Flufenamic AcidIBA 01/2016

Therapy/Procedure

4	Drug Therapy (Chemotherapy) 01/2018 - 05/2013
3	Therapeutics 01/2020 - 04/2012
3	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 01/2018 - 04/2004
2	Defibrillators (Defibrillator) 01/2018 - 05/2016
2	Resuscitation 01/2018 - 07/2003
1	Polypharmacy 01/2020
1	Ligation 03/2017